In a break from tradition, the race will take place on a Saturday night in November 2023 with the date yet to be finalised.
The famous Las Vegas Strip will act as the backdrop for the race sweeping past the city’s iconic casinos and landmarks.
It joins the United States Grand Prix in Austin, Texas, and the Miami Grand Prix, which makes its debut in May, on the 2023 calendar as F1 bosses look to widen the sport’s reach in the United States.
The track itself will be 3.8miles with cars reaching a top speed of 212mph and the race taking place over 50 laps with three main straights and 14 corners.
Formula 1 CEO Stefano Domenicali said: “This is an incredible moment for Formula 1 that demonstrates the huge appeal and growth of our sport with a third race in the US.
“Las Vegas is a destination known around the world for its excitement, hospitality, thrills, and of course, the famous Strip. There is no better place for Formula 1 to race than in the global entertainment capital of the world and we cannot wait to be here next year.”
F1 has previous history in Las Vegas with a race on the calendar in 1981 and 1982 under the name of the Caesars Palace Grand Prix.